O Brother, Where Art Thou? is a 2000 adventure comedy film written, produced, edited, and directed by Joel and Ethan Coen, and starring George Clooney, John Turturro, and Tim Blake Nelson, with John Goodman, Holly Hunter, and Charles Durning in supporting roles. Set in 1937 rural Mississippi[5] during the Great Depression, the film's story is a modern satire loosely based on Homer’s epic poem, Odyssey.